RPS6KB1 and obesity due to melanocortin 4 receptor deficiency: Considering that inhibition of mTOR-S6K signaling has attracted a great deal of attention in connection with health and longevity [12], [36], [37], evodiamine might be a unique compound able to combat obesity and age-related diseases; however, the effects of evodiamine on energy metabolism in other metabolic tissues remain to be clarified.