Of interest, we observed only one canonical pathway related to brain parenchyma response to MRT (“Huntington's disease signaling”) which includes genes related to apoptosis (Caspase 1, 3, 7, 8, 12, bax, TP53), intracellular signaling (GNG2, GNG11, CREB3, PRKCH, PRKCD) and one is neuron-specific (CACNA1B). Here, CREB3 is linked to juvenile Huntington disease.