CD8A and infection: B6 mice depleted of CD8 T cells prior to infection with the medium dose of LCMV also had significantly less weight loss and decreased mortality than the WT controls (Figure 1C) without a significant difference in viral load in the spleen at day 13 post infection (log10 pfu/spleen: B6 4.9 ± 0.5 SEM; anti-CD8 tx 5.3 ± 0.07 n = 5–9/group).