BIRC2 and ovarian neoplasm: Another DUB from the ovarian tumor (OTU) domain family of DUBs, A20, potentially regulates non-canonical NF-κB signaling in non-enzymatic fashion by disrupting interaction between c-IAP1 and TRAF2/TRAF3, thereby breaking the link between E3 ligase c-IAP1 and its substrate NIK (67).