Since Bcl-2 family proteins determine cell fate, we analyzed a publicly available library of Affymetrix gene expression levels from 44 MGUS and 414 newly diagnosed MM patients to investigate (a) the global change of Bcl-2 family members in MM versus MGUS and (b) whether the four major MM subtypes, defined as respectively hyperdiploid (HY) or IgH translocation in 11q13 (CCND1), 16q23 (MAF), and 4p16 (MMSET), display specific apoptotic machineries. The gene discussed is NSD2; the disease is Miyoshi myopathy.