KIR2DL4 and B-cell chronic lymphocytic leukemia: Maki et al. (18) reported in CLL cells an increased expression of HLA-G1, a class I molecule that engages NK-cell inhibitory molecules and which has for ligand p49/KIR2DL4/CD158d (expressed on NK cells and a fraction of T cells), ILT-2 [expressed on NK, T, B cells, dendritic cells (DC), and monocytes], and ILT-4 [expressed on antigen-presenting cells (APC)] (42).