Positive expression of iRs such as PD1, CTLA-4, TIM3, LAG-3, 2B4, CD160, and BTLA has been directly linked to reduced cytokine production by T cells from cancer patients (including reports from our group) or in the chronic LCMV mouse model of “T cell exhaustion” and other viral infections (7, 13, 19–23). The gene discussed is CD160; the disease is viral infectious disease.