Moreover, ACE inhibitors and ARBs change the balance of the RAAS augmenting angiotensin-(1–7) levels, and this may be important during aging (and consequently for old patients with heart disease and hypertension), when deficiency of this peptide also contributes to impairments in baroreflex sensitivity (Iyer et al., 1998). The gene discussed is ACE; the disease is hypertensive disorder.