In particular, an observational study on elderly women with hypertension confirmed that ACE inhibitors slowed the decline in physical function and muscle strength when compared with other antihypertensive agents and in a randomized placebo-controlled trial, ACE inhibitors permitted a significant enhancement in exercise capacity among elderly patients with heart failure (Onder et al., 2002; Henriksen and Jacob, 2003). This evidence concerns the gene ACE and heart failure.