CAV1 and systemic sclerosis: Caveolin 1 expression is decreased in many human fibrosis tissues including SSc skin and lung, IPF lung and keloid-derived fibroblasts, which suggest that the caveolin 1-mediated regulatory pathway may represent a new therapeutic opportunity in fibrotic diseases (Wang et al., 2006; Del Galdo et al., 2008a,b; Zhang et al., 2011).