Current drug discovery approaches in AD have focused on (i) preventing Aβ formation or increasing “normal” APP processing through the inhibition of γ- and β-secretase or the activation of α-secretase activity (Palop and Mucke, 2010; Saido and Leissring, 2012; Schenk et al., 2012); removing existing amyloid deposits via immunotherapeutic approaches, e.g., antibodies or vaccines against amyloid (Schenk et al., 2012). The gene discussed is APP; the disease is Alzheimer disease.