According to functional and biochemical analyses, P2X4 and P2X6 subunits are endogenously expressed in P19 murine embryonal carcinoma cells and show varying expression levels during the non-differentiated and neuronal progenitor states, suggesting a possible role for heteromeric P2X4/6Rs in regulation and induction of neurogenesis (Resende et al., 2007, 2008). This evidence concerns the gene P2RX6 and embryonal carcinoma.