Indeed, rimonabant reduces the consumption of standard food in food-deprived animals (Colombo et al., 1998), and CB1-deficient mice consume less food than wild-type littermates and are resistant to diet-induced obesity (Di Marzo et al., 2001; Cota et al., 2003). This evidence concerns the gene CNR1 and obesity due to melanocortin 4 receptor deficiency.