Since, OX1 signaling in LDT, DR, and LC promotes arousal, but is not necessary for consolidated spontaneous waking, orexin signaling at these loci may promote context-dependent arousal associated with, for example, stress, anxiety, panic, and/or food and drug seeking behavior (Winskey-Sommerer et al., 2004; Boutrel et al., 2005; Harris et al., 2005; Nair et al., 2008; Johnson et al., 2012; Piccoli et al., 2012; Steiner et al., 2012; Heydendael et al., 2013). Here, HCRT is linked to Anxiety.