Shortly after MI, the classically activated M1 macrophage (inducible nitric oxide synthase (Nos2, iNOS), MHC Class II, CD80, CD86) is present in the heart, which is strongly associated with the clearing of debris, inflammation, and the production of pro-inflammatory cytokines, such as IL-1β, TNF-α, and IFN-γ [97]. Here, NOS2 is linked to myocardial infarction.