Our data revealed that splenocytes isolated from LTS mice had a significantly greater proportion of IFNγ-producing CD8+ T cells following co-culture with irradiated CT26 tumor cells when compared to age-matched tumor-naïve mice (18.1 ± 2 vs. 0.8 ± 0.1%; LTS and naïve mice, respectively) (Fig. 4a; p < 0.001). Here, CD8A is linked to neoplasm.