Our results suggest that MMP-1-1607 1G/2G polymorphism was significantly associated with bladder cancer risk under recessive model, and significant association was found between MMP-2-1306 C/T polymorphism and bladder cancer risk under homozygote model, but there is no association found between MMP-9-1562 C/T polymorphism and bladder cancer risk. The gene discussed is MMP1; the disease is urinary bladder cancer.