MTOR and cancer: Although such a beneficial (and completely unsuspected) activity of rapalogs was initially ascribed to their capacity to robustly inhibit the mammalian target of rapamycin (mTOR) complex 1 (mTORC1) in cancer cells, accumulating preclinical evidence indicates that the therapeutic and oncopreventive effects of rapamycin-like compounds originates, at least in part, from cancer cell-extrinsic mechanisms that involve the immune system [61].