The present study has provided the first evidence concerning the role of XB130 in GC, showing that (1) XB130 contributes to GC cell proliferation and invasiveness, (2) XB130 is involved in phosphorylation of Akt and EMT-like changes, and (3) XB130 could be a potential therapeutic target in patients with GC. The gene discussed is AKT1; the disease is gastric cancer.