INS and polycystic ovary syndrome: In fact, it improves not only the systemic insulin sensitivity and serum androgen levels in PCOS patients [1,2] but also their ovarian morphology [3] and environment [2] by improving the intra-ovarian hyperandrogenism through local effect on ovarian steroidogenesis [4] and the intra-ovarian insulin-resistance [2,3] interfering with autocrine/paracrine insulin-related signaling [5,6].