PLOD1 and hyperandrogenism: In particular, PCOS was diagnosed by the presence of oligomenorrhea, clinical and biochemical signs of hyperandrogenism, polycystic ovaries (PCO) and follicle stimulating hormone (FSH)/luteinizing hormone (LH) level higher than 2 in 1 RCT [20], whereas it was diagnosed by the presence of oligomenorrhea (an interval of at least 56 days between menses) or amenorrhea (an interval of at least 6 months between menses) in the other one RCT [22].