IGF1R and hepatocellular carcinoma: The growth-inhibitory effects of NVP-AEW541 (IGFR inhibitor), MK2206 (Akt inhibitor), BEZ235 (PI3K/mTOR dual inhibitor), and RAD001 (mTOR inhibitor) on HCC cells and HUVEC were shown in Figure 1A. The response of the HCC cell lines tested to individual MTAs did not differ significantly from one another.