Whereas, among patients with cervical precancerous diseases without herpetic infection in clinical form, the IgM antibodies to HSV-1 and/or HSV-2 [30] were absent in their serum; it is likely that the presence of low- and medium-avidity IgG antibodies to HSV-1 and/or HSV-2 shows the final stage of primary HSV infection or exacerbation of a chronic process. Here, CD40LG is linked to infection.