Furthermore, most symptoms of CM including fever, renal failure, microangiopathic haemolytic anaemia, neurological deficits and thrombocytopaenia, are commonly found in thrombotic thrombocytopaenic purpura (TTP), a rare life-threatening disease, which is caused by a congenital or acquired deficiency of ADAMTS13. Here, ADAMTS13 is linked to thrombotic thrombocytopenic purpura.