The patients with Diffuse large B cell lymphoma (DLBCL) were treated with chemotherapeutic drugs alone–CHOP (Cyclophosphamide Hydrochloride Doxorubicin, Oncovin, prednisone) protocol until 2000 and R (Rituximab)-CHOP since 2000. This evidence concerns the gene DDIT3 and diffuse large B-cell lymphoma.