We have found that strong inhibition of SIRT2 by 100 nM SIRT2 siRNA or 10 μM AGK2, a widely used SIRT2 inhibitor [88, 93], can reduce the basal survival of PC12 cells and C6 glioma cells, thus suggesting toxic effects of strong inhibition of SIRT2 [90, 94]. The gene discussed is SIRT2; the disease is central nervous system cancer.