A latest study has shown that decreased SIRT1 activity by either pharmacological or genetic approach can lead to increased ischemic brain injury in a mouse model of permanent cerebral ischemia [107], which may be mediated by the effects of the SIRT1 inhibition/deletion on acetylation of p53 [80, 81] and NFκB [83, 84]. This evidence concerns the gene NFKB1 and brain ischemia.