Amongst the molecules that mediate intercellular adhesion and facilitate vasoocclusion in SCD, p-selectin occupies a strategic position because it is the one molecule involved in the adhesion of all three types of blood cells (erythrocytes, leukocytes, and platelets) not only to the vascular endothelium, but also to each other [8, 9]. The gene discussed is SELP; the disease is Schnyder corneal dystrophy.