In addition, omega-3 fatty acids reduce expression of intercellular adhesion molecule-1 (ICAM-1), leukocyte adhesion to vascular endothelium, and production of four biologically active molecules involved in the pathophysiology of tissue damage in SCD: interleukins (IL)-1β, -6, and -8 and tumour necrosis factor-alpha [10]. This evidence concerns the gene ICAM1 and Schnyder corneal dystrophy.