In AAM, we observed an increased PCa risk at HNF1B rs7501939 (recessive model: OR = 2.42, 95%  CI = 1.31–4.47, P = 0.0046; additive model: OR = 1.56, 95% CI = 1.08–2.27, P = 0.0193) and a decreased PCa risk at HNF1B rs4430796 (dominant model: OR = 0.57, 95% CI = 0.34–0.97, P = 0.0383; additive model: OR = 0.67, 95% CI = 0.46–0.99, P = 0.0431). The gene discussed is HNF1B; the disease is posterior cortical atrophy.