Although it is conceivable that elimination of CPEB4 could have resulted in compensatory mechanisms through which another CPEB substitutes for memory function normally exerted by CPEB4, it is also possible that the abundant expression of CPEB4 in the hippocampus may have other functions except learning and memory, possibly like promoting neuronal survival after cerebral ischemia [16]. Here, CPEB1 is linked to Cerebral ischemia.