Interestingly, however, although glial precursors are highly dependent upon NG2/CSPG4 and its PDGF-co-receptor activity, experimentally induced gliomagenesis through forced overexpression of PDGF is indistinguishable in wild type and NG2/CSPG4-KO mice [28], suggesting that (at least in the mouse) NG2/CSPG4 is not involved in the inception of glioblastoma through dysregulation of the signalling induced by this proto-oncogene. Here, CSPG4 is linked to glioblastoma.