Comparative immunoblotting of tissue extracts derived from regions of the human foetal brain rich in NG2/CSPG4-expressing neovascular pericytes substantiated the presence of diverse isoforms of the PG on these cells and highlighted a widespread proteolytic fragmentation of the extracellular domain, which seemed different in human foetal brain as compared to glioblastoma lesions and cultured melanoma cell lines. The gene discussed is CSPG4; the disease is glioblastoma.