Comparative immunoblotting of tissue extracts derived from regions of the human foetal brain rich in NG2/CSPG4-expressing neovascular pericytes substantiated the presence of diverse isoforms of the PG on these cells and highlighted a widespread proteolytic fragmentation of the extracellular domain, which seemed different in human foetal brain as compared to glioblastoma lesions and cultured melanoma cell lines. This evidence concerns the gene CSPG4 and melanoma.