RPN2 and breast cancer: Recently, Honma et al [27] reported that downregulation of ribophorin II (RPN2)) promoted docetaxel-dependent apoptosis and cell growth inhibition of MCF7-ADR human breast cancer cells that are resistant to docetaxel It also has been found that RPN2 suppression increased sensitivity to docetaxel in oesophageal squamous cell carcinoma in vitro [53].