Expressing the longest human tau isoform, 2N4R, in SH-SY5Y neuroblastoma cells, causes significant deformity of the nuclear compartment, with extensive lobulations along the nuclear envelope, and alterations of the assembly of the tubulin cytoskeleton, which is modified from a radial organization to a more peripheral and perinuclear distribution in the form of thick rings [39]. This evidence concerns the gene MAPT and neuroblastoma.