CHGA and infection: Other than within the transcriptome profile, we were unable to identify a phenotype for S. Typhi or S. Typhimurium harboring mutations in yehUT. Despite the transcriptome analysis of S. Typhi ΔyehUT revealing dysregulation of a number of SPI genes yehUT mutant derivatives were able to invade cultured epithelial cells at rates comparable to control and showed no difference the mouse infection models compared to the parental strain.