Notably, Hui Cai and colleagues genotyped 3 tagging SNPs of CCNB1 in 1449 newly diagnosed endometrial cases from Shanghai Cancer Registry in China, and found that rs2069433 was related to a reduction in endometrial cancer risk [18], however, no significant association was observed between rs2069433 and breast carcinoma susceptibility in our study. Here, CCNB1 is linked to cancer.