In addition, SNPs in the postmeiotic segregation increased 2 (PMS2), TNIP1, caspase recruitment domain family, member 11 (CARD11), ITGAM, BLK and interleukin-1 receptor-associated kinase 1 (IRAK1) genes were associated with LN with p-values <0.001 and OR between 1.53 and 2.21 (Table? The gene discussed is IRAK1; the disease is lobular neoplasia.