BEST2 and infection: However, at 14 days post infection (i.e. start of clearance), there appears to be distinct differences compared to the other time points: the relationship between the Im responses are changed, and there was a 6-fold change in the ratio between the change in Rp in response to carbachol (p<0.05) and similarly a 6-fold increase in the ratio between the nominally increased Bestrophin-2 and decreased Cftr mRNA (p<0.05).