SFRP1 and fibrosis: For example, we had 96% power to identify SFRP2 rs1547711186 for risk of fibrosis (155 advanced and 270 mild fibrosis patients), based on the SNP have MAF of 0.28 and confer OR of 2.18 in a dominant model; we had 97% power to identify SFRP1 rs16890282 associated with risk of inflammation (180 advanced and 245 mild inflammation patients), based on the variant having an MAF of 0.18 and conferring an OR of 2.15 in a dominant model.