Analyzing only anagen VI HFs, quantitative immunohistomorphometry of the proliferation marker Ki-67 showed that, compared to scrambled control HFs, β1 integrin-specific silencing significantly reduced the number of Ki-67+ cells (10% less than scrambled control) in the maximally proliferating hair matrix (Figure 1C), and also significantly reduced the number of slow-cycling Ki-67+ cells in the HF bulge (Figure 1D). Here, MKI67 is linked to Hand-foot syndrome.