SKP2 and neoplasm: It has been reported that aberrant STAT3 activation promotes uncontrolled tumor cell growth and survival through multiple mechanisms, including increased expression of oncogenes, such as c-myc, Skp2, and cyclin D1, as well as antiapoptotic proteins, including Bcl-2, Bcl-xL, Mcl-1, and survivin [33]–[35].