Our results suggest the integrated signaling in that CD44 interact with STAT3, STAT3 gets phosphorylated and translocated into the nucleus, then pSTAT3 binds NF-kB and activates hTERT and hTERT, in return, activates the CD44 expression in a feedback fashion in the constitutively activated STAT3 cancer cells. Here, NFKB1 is linked to cancer.