Because the surface levels of HM1.24 have been demonstrated to correlate well with the cytotoxic activity of AHM or YB-AHM against MM cells [35], [36], the up-regulation of HM1.24 expression on the surface of MM cells may contribute to the enhancement of ADCC by YB-AHM plus Len treatment. This evidence concerns the gene BST2 and Miyoshi myopathy.