In patients with COPD, one month treatment with budesonide/formoterol significantly increased BAL concentrations of pro-SFTPB by a median (interquartile range) of 62.46 ng/ml (−50.62 to 264.04) (p = 0.022), representing a 48.7% from the baseline median value (Figure 2). The gene discussed is SFTPB; the disease is chronic obstructive pulmonary disease.