Other proteins, including bone morphogenetic protein 1, cyclophilin A, high mobility group protein B1, macrophage migration inhibitory factor, S100A11, Thrombospondin-1, TNF receptor-associated factor 6, toll-like receptor 4, and 14-3-3 protein gamma, are involved in promotion of inflammation, ROS production, cell proliferation, cardiovascular remodeling, neurodegeneration and tumor growth in vitro and in vivo through various mechanisms as reported previously (Table S1). Here, TLR4 is linked to neoplasm.