Increased Dicer protein expression was associated with adverse prognostic features in cancers of the prostate [41], ovary [42], colon [44], in malignant melanomas [45], soft tissue sarcomas [46] and nasopharyngeal carcinomas [47], whereas low protein expression was associated with tumour invasiveness, metastasis and poor survival in carcinomas of the gallbladder [48], colon [49], ovary [50], and breast [17]. The gene discussed is DICER1; the disease is melanoma.