To generate a fly model for mortalin-associated PD, we used a targeted knockdown of Hsc70-5, the Drosophila homolog of human mortalin. We found that pan-neuronal silencing of Drosophila mortalin by RNA interference (RNAi) resulted in reduced fly viability, locomotion impairment, body posture defects, and reduced ATP levels. The gene discussed is HSPA9; the disease is Parkinson disease.