Cell cycle-dependent expression of Arhgap11a was also detected in other colon cancer cell lines besides HCT116, such as DLD1, HT29 and KM125M (Figure 2F) and HeLa (Figure S5) as well as in non-cancer cell lines such as HEK293 cells (Figure S6), suggesting the presence of a general mechanism for this characteristic expression regulation of Arhgap11a in many cell types. Here, ARHGAP11A is linked to malignant colon neoplasm.