Finally, a previous study has shown miR-720 transcribed downstream from the co-transcriptional factor Ski-related novel gene (SnoN/SKIL) in esophageal squamous cell carcinoma (ESCC) cells [39], and that down-regulation of SnoN decreased the levels of miR-720 as well as ESCC cell proliferation. This evidence concerns the gene AQP1 and esophageal squamous cell carcinoma.