miRNAs of the L1 library (tumour-derived miRNAs from control animals) and L3 library (serum miRNAs from control animals) were sorted by abundance score (RPKM values) in descending order and the data of the L2 library (tumour-derived miRNAs from animals treated with RNase A) and L4 library (serum miRNAs from animals treated with RNase A) were superposed, respectively. Here, RNASE1 is linked to neoplasm.