PPIA and familial pancreatic carcinoma: We found that Keap1, Nrf2, PPIA, Prdx6 and CD147 were not significantly correlated with tumor stage, lymph node status, pathological grade, but the results were same as in pancreatic cancer [22], [23], the association between the levels of Nrf2 or Keap1 with clinicopathological parameters was also not significant, which indicating that large number of cases may be needed to clarify in future study.