According to other researches in non-small-cell lung cancer [27], Nrf2 and Keap1 were closely related to outcome and could be independent prognostic factors, we suggest that Nrf2 and Keap1 were correlated with oral cancer prognosis, and large number of cases study will be explored to identify this suggestion. This evidence concerns the gene KEAP1 and non-small cell lung carcinoma.