GPR183 and type 1 diabetes mellitus: A SNP associated with T1D was found to lower Ebi2 expression and increase expression levels of IDIN genes, and ablation of Ebi2 expression in rat macrophages increased expression of Irf7 and IDIN genes, suggesting that Ebi2 is a negative regulator of macrophage/monocyte responses [32], As IRF7 is the master regulator of IFN-α expression and pDC are the primary producers of IFN-α [12], a corollary to the association between EBI2 and type T1D would be dysregulated pDC function.