Recently, Chatterjee et al. [50], [51] demonstrated that all the three dsRNAs receptors, TLR-3, RIG-I and IFIH1, are activated in placentas of mice and women with preeclampsia (PE), a pregnancy-specific syndrome characterized by excessive maternal immune system activation, inflammation, and endothelial dysfunction, causing hypertension. Here, RIGI is linked to endothelial dysfunction.