The proinflammatory cytokine profiles in the diabetes mellitus patients, including IL-8, were correlated with severity of the course of disease [40-43] and polymorphisms of pro-inflammatory cytokine genes (CCL2, TGFB1, IL8, CCR5, and MMP9) were found to be associated with the risk of diabetic nephropathy [44]. The gene discussed is MMP9; the disease is diabetic kidney disease.