However, a case-control study of 132 ovarian carcinoma patients with primary ovarian carcinomas and 264 controls in parallel from New York (USA), Umea (Sweden) and Milan (Italy) did not reveal a strong relation between increasing circulating SHBG and ovarian carcinoma risk [41], also confirmed by Rinaldi and coworkers [42]. The gene discussed is SHBG; the disease is ovarian carcinoma.