Then we extended this study to 248 ovarian carcinoma patients, in order to explore whether SHBG is expressed in the human ovarian carcinomas and furthermore analyze the associations between the local SHBG expression and clinicopathological features, including age, histological subtype, histological grade (grade of differentiation), International Federation of Gynecology and Obstetrics stage (FIGO stage), overall survival (OS) and progression free survival (PFS). The gene discussed is SHBG; the disease is ovarian carcinoma.